July 25, 2024
Personalized Medicine

Newly Discovered RNA Modification Contributes to Mitochondrial Dysfunction and Energy Deprivation in Alzheimer’s Disease

A groundbreaking study conducted by researchers at Johannes Gutenberg University Mainz (JGU) has unveiled a novel mechanism responsible for mitochondrial dysfunction in Alzheimer’s patients, leading to a decrease in energy production for the brain.

Professor Kristina Friedland from the Institute of Pharmaceutical and Biomedical Sciences at JGU, who oversaw the research, explained, “Our findings reveal an unprecedented RNA modification that contributes to the disruption of mitochondrial protein synthesis in Alzheimer’s disease.” She collaborated on the project with Professor Mark Helm.

The team’s results offer valuable insights into the pathophysiology of Alzheimer’s disease. Researchers from the Mainz University Medical Center, the Institute of Molecular Biology (IMB), Universit√© de Lorraine, and the Medical University of Vienna also contributed to the study. The study’s corresponding paper was published in Molecular Psychiatry.

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