May 22, 2024
Allergic Asthma

Unraveling the Connection between Iron and Allergic Asthma: New Insights and Potential Therapeutic Approaches

A recent study published in the journal Science Translational Medicine by researchers from the Keck School of Medicine of USC sheds light on the role of iron in the development of allergic asthma and offers promising new avenues for treatment.

During an allergic asthma attack, group 2 innate lymphoid cells (ILC2s) can become overactive, leading to excessive inflammation and narrowing of the airways. Although the underlying biology is not well understood, this new research reveals that ILC2s require iron to function optimally.

The team conducted experiments using both human cells and mouse models to explore the link between ILC2s and iron. They discovered that ILC2s utilize iron to fuel various cellular processes, making it a crucial component in activating these immune cells. In mice, inhibiting iron uptake in ILC2s lessened the severity of asthma symptoms.

In human cells, increased ILC2 activity and iron uptake were linked to the severity of asthma, suggesting that ILC2s and iron play a significant role in more severe cases of the disease. These findings could pave the way for new therapies aimed at targeting iron metabolism in ILC2s to alleviate symptoms for patients with asthma and other Allergic Rhinitis Treatment conditions.

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