Colorectal cancer patients who also have diabetes, especially those with complications related to diabetes, face a higher risk of early death, according to a study published in the peer-reviewed journal CANCER. The study analyzed data from the Taiwan Cancer Registry Database, which included information on 59,202 individuals with stage I-III colorectal cancer who underwent surgery. Of these patients, 9,448 experienced cancer recurrence and 21,031 died during the study period.
The study found that individuals with uncomplicated diabetes had a slightly higher risk of all-cause and cancer-specific death compared to those without diabetes. However, those with complicated diabetes had an 85% higher risk of death from any cause and a 41% higher risk of death from cancer. These associations were more significant in women and patients with early-stage colorectal cancer.
In addition, patients with uncomplicated or complicated diabetes had a 10-11% higher risk of colorectal cancer recurrence compared to patients without diabetes.
The researchers believe that the relationship between diabetic severity and poor colorectal cancer prognosis could be attributed to various factors, including elevated insulin and glucose levels in the blood, as well as chronic inflammation commonly seen in type 2 diabetes.
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